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Wegovy & Saxenda

What's New With Weightloss: Wegovy & Saxenda

SAXENDA® is a glucagon-like peptide 1 (GLP-1) receptor agonist indicated as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in: Adult patients with an initial body mass index (BMI) of • 30 kg/m2 or greater (obese), or • 27 kg/m2 or greater (overweight) in the presence of at least one weight-related comorbid condition (e.g. hypertension, type 2 diabetes mellitus, or dyslipidemia).

 

You may have heard that there is a new class of weight-loss medications that are incredibly effective at curbing appetite, improving blood sugar control and promoting profound weight-loss. This group of medications is known as glucagon-like peptide 1 agonists, or GLP-1. This group of GLP-1 medications come in a variety of names, dosages and frequency of dosing, but they all act in one common way, they inhibit the hunger hormone, leptin. It is this hormone, leptin, that controls our hunger, whether it induces us to eat more or to realize we are full, depending on the level of the leptin hormone. Unfortunately, like insulin resistance, many people develop leptin resistance, in that even though the leptin level may be elevated, sending a message to our brain that we should be full, we become resistant to that message and remain un-satiated which leads to overeating. By restoring leptin sensitivity, hunger is controlled, and we are able to shed excess weight.

Weight loss

 

Losing weight with Saxenda and fast and easy

Here at Renove Medical Spa, we have found that treating our patients with GLP-1 agonists has been very effective at promoting significant weight loss, quickly and easily, with minimal side effects. Many of our patients have lost 10 pounds in 4 weeks with sustained weight-loss at that rate for 3 months, with patients reaching their goal weights in several months. We offer medication administration training and ongoing counseling during use of your treatment with a GLP-1 medication.

 

There are two Medications in the GLP-1 agonists class that are FDA approved for weight loss, Wegovy and Saxenda. There are other GLP-1 agonists that are approved for diabetes management. These medications are generally taken by a shot (injection) given daily or weekly. This should not be a deterrent to anyone, as the needle size is very small, and the auto-injector is very easy for anyone to use.

 

For Weight Loss:

  • Semaglutide (Wegovy) (weekly)

  • Liraglutide (Saxenda) (daily)

For Diabetes:

  • Dulaglutide (Trulicity) (weekly)

  • Exenatide extended release (Bydureon bcise) (weekly)

  • Exenatide (Byetta) (twice daily)

  • Semaglutide (Ozempic) (weekly)

  • Liraglutide (Victoza) (daily)

  • Lixisenatide (Adlyxin) (daily)

  • Semaglutide (Rybelsus) (taken by mouth once daily)

The downside to GLP-1 drugs is that all but one has to be taken by a shot. And, like any drug, there is a risk of side effects, some serious. Side effects most commonly occur initially, just as you begin the medicaiton, such as transient stomach cramping. This is why dosages are increased slowly. More common side effects often improve as you continue to take the drug for a while.

Some of the more common side effects include:

  • Abdominal cramping

  • Dehydration

  • Nausea

Dehydration occurs because this class of medication can also inhibit thirst as much as hunger, so often people don't get the thirst cues to drink more water. Therefore planning to drink plenty of water is part of the regimen when prescribed these medications. The GLP-1 class of drugs isn't recommended if you have a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia.

 

If you are interested in losing weight with a GLP-1 medication, you may wish to start by contacting your insurance company to see if any of the above medications are covered by your health insurance, as the price on the free market is VERY expensive, approximately $400 to $1,300 per month. We also provide training on the self injection technique, counseling and monthly follow up for you GLP-1 weight loss journey for best results.

 

If you would like to see if you are a good candidate for our weight loss program with a GLP-1 agonist, please call for an appointment with Dr. Michelle Parsons, M.D. at 302-227-1079 or book online here .

Saxenda Daily Injection for Weight Loss

SAXENDA® is a glucagon-like peptide 1 (GLP-1) receptor agonist indicated as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in: Adult patients with an initial body mass index (BMI) of • 30 kg/m2 or greater (obese), or • 27 kg/m2 or greater (overweight) in the presence of at least one weight-related comorbid condition (e.g. hypertension, type 2 diabetes mellitus, or dyslipidemia).

Dosage Forms & Strength

Injection: 6 mg/mL solution in a 3 mL pre-filled, single-patientuse pen that delivers doses of 0.6 mg, 1.2 mg, 1.8 mg, 2.4 mg or 3 mg.

  • Week 1 administer 0.6 mg daily

  • Week 2 administer 1.2 mg daily

  • Week 3 administer 1.8 mg daily

  • Week 4 administer 2.4 mg daily

  • Week 5 administer 3 mg daily - Maintenance dose

 

Contraindications

  • Personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome t

  • Hypersensitivity to liraglutide or any excipients in SAXENDA®

  •  Pregnancy

Warnings & Precautions

  • Thyroid C-cell Tumors

  • Acute Pancreatitis:

    • Discontinue promptly if pancreatitis is suspected. Do not restart if pancreatitis is confirmed.

  • Acute Gallbladder Disease:

    • If cholelithiasis or cholecystitis are suspected, gallbladder studies are indicated.

Wegovy (Semaglutide) Injection

WEGOVY® (semaglutide) injection 2.4 mg is an injectable prescription medicine that may help adults and children aged ≥12 years with obesity (BMI 30 for adults, BMI ≥ 95th percentile for age and sex for children), or some adults with excess weight (BMI ≥27) (overweight) who also have weight-related medical problems to help them lose weight and keep it off. Wegovy® should be used with a reduced calorie meal plan and increased physical activity.

Wegovy® contains semaglutide and should not be used with other semaglutide-containing products or other GLP-1 receptor agonist medicines​

Warnings & Precautions

Wegovy® may cause serious side effects, including:

  • Possible thyroid tumors, including cancer. 

    • Tell your healthcare provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. 

  • inflammation of your pancreas (pancreatitis). 

  • gallbladder problems. 

  • increased risk of low blood sugar (hypoglycemia) in patients with type 2 diabetes, especially those who also take medicines for type 2 diabetes such as sulfonylureas or insulin. 

  • kidney problems (kidney failure)

    • In people who have kidney problems, diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration), which may cause kidney problems to get worse.

  • serious allergic reactions. 

  • change in vision in people with type 2 diabetes

  • increased heart rate

  • depression or thoughts of suicide. 

Do not use Wegovy® if:

  • you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC) or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

  • you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC) or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

  • you have had a serious allergic reaction to semaglutide or any of the ingredients in Wegovy®

Before using Wegovy®, tell your healthcare provider if you have any other medical conditions, including if you:

  • have or have had problems with your pancreas or kidneys

  • have type 2 diabetes and a history of diabetic retinopathy

  • have or have had depression, suicidal thoughts, or mental health issues

  • are pregnant or plan to become pregnant. 

  • are breastfeeding or plan to breastfeed.

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